The endless little stream of sensation (6)
I believe the answer is:
thrill
'sensation' is the definition.
(thesaurus)
'the endless little stream' is the wordplay.
'endless' means to remove the last letter.
'little stream' becomes 'rill' (I've seen this before).
'the' with its last letter taken away is 'th'.
'th'+'rill'='THRILL'
'of' acts as a link.
(Other definitions for thrill that I've seen before include "Stimulating sensation, wave of excitement" , "Tingling feeling of excitement" , "Excited feeling" , "Sudden sensation of excitement" , "Kick" .)