"The Forsyte Saga" wife (5)
I believe the answer is:
'the forsyte saga wife' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for irene that I've seen before include "Greek godess of peace" , "- - Handl, actress" , "Goddess of peace - Byzantine ruler" , "Representative of peace" , "Peaceful girl" .)