The Guardian and Independent read inside out? Strange (5)
I believe the answer is:
weird
'strange' is the definition.
('weird' can be a synonym of 'strange')
'the guardian and independent read inside out?' is the wordplay.
'the guardian' becomes 'we' (I can't explain this - if you can you should believe this answer much more).
'and' is a charade indicator (letters next to each other).
'independent' becomes 'i'.
'inside out?' means to remove the middle letters (throwing the inside away).
'read' with its centre removed is 'rd'.
'we'+'i'+'rd'='WEIRD'
(Other definitions for weird that I've seen before include "Uncanny, bizarre" , "Strange, peculiar" , "Creepy" , "behaving erratically?" , "Unearthly" .)