The miseries of disheartened Wombles (4)
I believe the answer is:
woes
'the miseries' is the definition.
(woe is a kind of misery)
'disheartened wombles' is the wordplay.
'disheartened' says to hollow out the word (remove centre letters).
'wombles' with its centre removed is 'WOES'.
'of' is the link.
(Other definitions for woes that I've seen before include "Misfortunes" , "Sorrows and heartaches" , "Troubles" , "Sufferings" .)