The ___, mission in San Antonio, Texas, that was the site of a siege and massacre by Mexican forces in 1836 (5)
I believe the answer is:
alamo
(Other definitions for alamo that I've seen before include "Mission building in Texas, site of famous siege by Mexico" , "US mission" , "Site of a Texas siege, 1836" , "ill-fated mission" , "Scene of massacre in Texas" .)