The most up-to-date come from the north-east and west (6)
I believe the answer is:
newest
'the most up-to-date' is the definition.
(I've seen this before)
'from the north-east and west' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'the north' becomes 'N' ('N' can be a synonym of 'north').
'east' becomes 'e' (synonyms).
'and' is a charade indicator (letters next to each other).
'n'+'e'='ne'
'ne' after 'west' is 'westne'.
'westne' with letters rearranged gives 'NEWEST'.
'come' is the link.
This may not be correct. It may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for newest that I've seen before include "Most recent or most fashionable" , "Superlatively modern" , "Most pristine or latest" , "Most recent or least worn" , "most up-to-date" .)