The occupant is at home with his wife (6)
I believe the answer is:
inmate
'the occupant' is the definition.
(inmate is a kind of occupant)
'at home with his wife' is the wordplay.
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'with' is a charade indicator (letters next to each other).
'his wife' becomes 'mate' (I've seen this in other clues).
'in'+'mate'='INMATE'
'is' acts as a link.
(Other definitions for inmate that I've seen before include "eg Prisoner" , "One is in jail" , "Lag" , "Occupant" , "One institutionally confined" .)