The only possibility is to lose (4)
I believe the answer is:
sole
'the only' is the definition.
(I've seen this before)
'possibility is to lose' is the wordplay.
'lose' anagrams to 'SOLE'.
Though, I am unsure how this is indicated.
Can you help me to learn more?
(Other definitions for sole that I've seen before include "swimmer" , "A lone sort of fish - lose it" , "Kind of fish - lose it" , "Flatfish; exclusive" , "Underside of footwear" .)