The orator’s unfortunate complaint (4,6)
I believe the answer is:
sore throat
'complaint' is the definition.
(sore throat is a kind of disease)
'the orator's unfortunate' is the wordplay.
'unfortunate' indicates anagramming the letters.
'the'+'orators'='theorators'
'theorators' with letters rearranged gives 'SORE THROAT'.
(Another definition for sore throat that I've seen is " Inflammation affecting speech".)
I've seen this clue in The Times.
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