The queen is in charge of the man
I believe the answer is:
eric
'the man' is the definition.
(I've seen this before)
'the queen is in charge' is the wordplay.
'the queen' becomes 'ER' (abbreviation for Elizabeth Regina).
'is in charge' becomes 'ic' (abbreviation for 'in charge').
'er'+'ic'='ERIC'
'of' is the link.
(Other definitions for eric that I've seen before include "Fine" , ".... the Red, Norwegian explorer who discovered Greenland in 10th century" , "Ernie's comic partner" , "Man" , "---- Cantona, Manchester Utd favourite of the 1990s" .)