The reek around the west and south would go through you. (6)
I believe the answer is:
skewer
'go through you' is the definition.
The definition suggests a singular noun which matches the answer.
'the reek around the west and south would' is the wordplay.
I cannot really see how this works, but
'west' could be 'w' (abbreviation) and 'w' is present in the answer.
an anagram of 'reek' is 'keer' which is present in the remaining letters.
'south' could be 's' (abbreviation) and 's' is found within the answer.
This accounts for all the letters.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for skewer that I've seen before include "Metal pin for cooking" , "Pin for meat etc" , "Pierce, impale" , "Stick on which kebab is cooked" , "Displayer of meat" .)