'The REM Introduction' begins with eerie instrument (8)
I believe the answer is:
theremin
'eerie instrument' is the definition.
(plays without human contact)
'the rem introduction begins' is the wordplay.
'introduction' suggests taking the first letters.
'begins' becomes 'emin' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
The first letter of 'rem' is 'r'.
'the'+'r'+'emin'='THEREMIN'
'with' acts as a link.
Can you help me to learn more?
I've seen this clue in The Everyman puzzle in The Observer.
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