The saint's awful blemish (5)
I believe the answer is:
stain
'blemish' is the definition.
(stain is a kind of blemish)
'the saint's awful' is the wordplay.
'awful' is an anagram indicator.
'saint' with letters rearranged gives 'STAIN'.
(Other definitions for stain that I've seen before include "Smear" , "Blotch on satin" , "Mark with colour, dirt" , "Discoloration" , "Blot" .)