The setter is cursed with old doctrine in Early English (3,2,2)
I believe the answer is:
woe is me
'the setter is cursed' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'with old doctrine in early english' is the wordplay.
'with' becomes 'w' (abbreviation).
'old' becomes 'o' (abbreviation).
'doctrine' becomes 'ism' (suffix for disciplines or schools of thought).
'in' is an insertion indicator.
'early english' becomes 'EE' (architectural abbreviation).
'ism' put inside 'ee' is 'eisme'.
'w'+'o'+'eisme'='WOE IS ME'
Can you help me to learn more?
(Other definitions for woe is me that I've seen before include "I'm poor person" , "I feel terrible" , "I'm dismayed" , "Alas and alack!" , "I'm fed up" .)