The twins in a spot of bother (4)
I believe the answer is:
both
'the twins in' is the definition.
Both the definition and answer are adjectives. Maybe you can see a link between them that I don't see?
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for both that I've seen before include "The two (things)" , "couple" , "The one and the other" , "Each of two (alternatives)" , "Two considered together" .)