The two English run to make trouble (6)
I believe the answer is:
bother
'trouble' is the definition.
('bother' can be a synonym of 'trouble')
'the two english run' is the wordplay.
'the two' becomes 'both' ('both' can be a synonym of 'the two').
'english' becomes 'e' (abbreviation).
'run' becomes 'r' (cricket abbreviation).
'both'+'e'+'r'='BOTHER'
'to make' acts as a link.
(Other definitions for bother that I've seen before include "Hassle - drat!" , "Trouble, fuss" , "Annoy or pester" , "Fuss and annoyance" , "Irritate - concern oneself" .)