There's nothing in Manila (3)
I believe the answer is:
nil
'there's nothing' is the definition.
(nil means a score of zero in football)
'in manila' is the wordplay.
'in' says the answer is hidden in the clue.
'NIL' is hidden in the letters of 'manila'.
(Other definitions for nil that I've seen before include "Nix, nada, nothing" , "Lacking value" , "duck" , "0" , "You get nothing" .)