These are vital instruments (6)
I believe the answer is:
organs
'instruments' is the definition.
(organ is a kind of instrument)
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for organs that I've seen before include "Groans over distinct parts of animal body" , "Heart and lungs are vital ones" , "Such as liver, heart, etc" , "Keyboard instruments and body parts" , "Air-powered keyboard instruments" .)