They give a direction in the entrances (6)
I believe the answer is:
donors
'they give' is the definition.
(I've seen this in another clue)
'a direction in the entrances' is the wordplay.
'a direction' becomes 'n' (compass direction north).
'in' indicates putting letters inside.
'the entrances' becomes 'doors' (door is a kind of entrance).
'n' put within 'doors' is 'DONORS'.
(Other definitions for donors that I've seen before include "They give things including blood" , "They give, blood say" , "They give, money or blood" , "Givers as of blood" , "They give to others, maybe blood" .)