They won't go off with US men that lack energy (4)
I believe the answer is:
duds
'they' is the definition.
Both the answer and definition are plural nouns.
Maybe they are linked in a way I don't understand?
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for duds that I've seen before include "Failures; clothes" , "Bombs that fail to explode" , "One assumes them" .)