They're driven home by twisters (6)
I believe the answer is:
screws
'twisters' is the definition.
Although both the answer and definition are plural nouns, I don't see how one could define the other.
I don't understand the rest of the clue.
Can you help me to learn more?
(Other definitions for screws that I've seen before include "Prison warders (sl.)" , "Grooved fastening devices" , "increase the pressure" , "Fastening devices and prison guards, colloquially" , "Fix in place (6)" .)