Think twice when axing leader for change (5)
I believe the answer is:
alter
'for change' is the definition.
(synonyms)
I cannot understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for alter that I've seen before include "Revise" , "Change, make different" , "Become different" , "Make changes to" , "Change or adjust" .)