Though soft and gentle, it can be serious (6)
I believe the answer is:
plight
'it can be serious' is the definition.
The definition suggests a singular noun which matches the answer.
'though soft and gentle' is the wordplay.
'though soft' becomes 'p' (musical abbreviation for 'piano', soft. I am not sure about the 'though' bit.).
'and' means one lot of letters go next to another.
'gentle' becomes 'light' (synonyms).
'p'+'light'='PLIGHT'
Can you help me to learn more?
(Other definitions for plight that I've seen before include "Serious predicament" , "Quandary, predicament" , "Unlucky situation; promise" , "Dilemma" , "Unfortunate position" .)