Three players heading for tour, going to South American city (4)
I believe the answer is:
trio
'three players' is the definition.
(three musicians)
'heading for tour going to south american city' is the wordplay.
'heading for' suggests taking the first letters.
'going to' says to put letters next to each other.
'south american city' becomes 'rio' (I've seen this before).
The initial letter of 'tour' is 't'.
't'+'rio'='TRIO'
(Other definitions for trio that I've seen before include "Band of three" , "Small group playing" , "Group of three (musicians)" , "Threesome" , "wise men?" .)