Thrust upwards and do damage (3)
I believe the answer is:
mar
'do damage' is the definition.
(marring is a kind of damaging)
'thrust upwards' is the wordplay.
'thrust' becomes 'ram' (ramming is a kind of thrusting).
'upwards' shows that the letters should be reversed in order.
'ram' backwards is 'MAR'.
'and' acts as a link.
(Other definitions for mar that I've seen before include "Blight" , "Spoil or deface" , "Spanish main?" , "'Impair, spoil (3)'" , "A windy month" .)