Thus do cupolas twitch at home! (8)
I believe the answer is:
domestic
'at home' is the definition.
(I've seen this before)
'thus do cupolas twitch' is the wordplay.
I cannot really see how this works, but
'do' is present in the answer.
'twitch' could be 'tic' (tic is a kind of twitch) and 'tic' is located in the answer.
The remaining letters 'mes' is a valid word which might be clued in a way I don't see.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for domestic that I've seen before include "Homely" , "of family affairs" , "of houses?" , "hired help" , "Household servant" .)