Thus fortify with alcohol for consolation (6)
I believe the answer is:
solace
'for consolation' is the definition.
(synonyms)
'thus fortify with alcohol' is the wordplay.
'thus' becomes 'so' (synonyms).
'fortify with alcohol' becomes 'lace' (as in lacing something with alcohol).
'so'+'lace'='SOLACE'
(Other definitions for solace that I've seen before include "Comfort in time of disappointment or sorrow" , "Comfort at a time of sadness" , "Comport" , "Kind of comfort - a close thing" , "console" .)