Tickle pals regularly to relax (6)
I believe the answer is:
please
'tickle' is the definition.
(I've seen this in another clue)
'pals regularly to relax' is the wordplay.
'regularly' indicates alternate letters (regularly take one letter, leave next etc.).
'to relax' becomes 'ease' (eg to ease a restriction is to relax it).
The alternate letters of 'pals' are 'pl'.
'pl'+'ease'='PLEASE'
(Other definitions for please that I've seen before include "Asleep (anag)" , "Delight; amuse" , "Make happy or glad" , "Gratify, make contented" , "Give satisfaction to" .)