Tie is a nuisance (4)
I believe the answer is:
bind
This clue is a double definition.
'tie' is the first definition.
(I know that tie can be written as bind)
'nuisance' is the second definition.
(I've seen this before)
'is a' acts as a link.
(Other definitions for bind that I've seen before include "Restrict" , "This weed" , "difficult situation" , "difficulty" , "Wrap tightly - nuisance" .)