Tie nun up harmoniously (2,4)
I believe the answer is:
in tune
'harmoniously' is the definition.
I don't know anything about this answer so I cannot judge whether this works.
'tie nun up' is the wordplay.
'up' indicates an anagram (letters get chucked up).
'tie'+'nun'='tienun'
'tienun' with letters rearranged gives 'IN TUNE'.
Can you help me to learn more?
(Other definitions for in tune that I've seen before include "agreeing" , "Conversant" , "Playing or singing at the correct musical pitch" .)