Tied up in RE, in a gloomy state (6)
I believe the answer is:
moored
'tied up' is the definition.
(I've seen this in another clue)
're in a gloomy state' is the wordplay.
'in' indicates putting letters inside.
'a gloomy state' becomes 'mood' (a depressed mood).
're' going within 'mood' is 'MOORED'.
'in' is the link.
(Other definitions for moored that I've seen before include "Of boat, secured by rope to shore" , "Secured by rope or cable" , "Berthed, tied up" , "Parked (of a boat)" , "Tied up to berth like ship or boat" .)