Ties up the location (4)
I believe the answer is:
site
'the location' is the definition.
(site is a kind of location)
'ties up' is the wordplay.
'up' is an anagram indicator.
'ties' is an anagram of 'SITE'.
(Other definitions for site that I've seen before include "Locale" , "Spot, location" , "Building plot" , "Building land" , "Position; situation" .)