Tight shirt restricting heaving bosom is a dangerous obstruction (10)
I believe the answer is:
thrombosis
'a dangerous obstruction' is the definition.
(obstruction of a blood vessel)
'tight shirt restricting heaving bosom' is the wordplay.
'tight' indicates anagramming the letters (tight can mean drunk).
'restricting' means one lot of letters goes inside another.
'heaving' is an anagram indicator (letters thrown or heaved around).
'shirt' is an anagram of 'thris'.
'bosom' anagrammed gives 'ombos'.
'thris' enclosing 'ombos' is 'THROMBOSIS'.
'is' acts as a link.
(Other definitions for thrombosis that I've seen before include "Blood clot" , "Complaint" .)