Tighten muff (5,2)

I believe the answer is:

screw up

This clue is a double definition.

'tighten' is the first definition.
(thesaurus)

'muff' is the second definition.
(synonyms)

(Other definitions for screw up that I've seen before include "Summon" , "Mishandle a situation" , "Bungle" , "Fail badly" , "Completely mismanage a situation" .)

I've seen this clue in The Times.

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