Tightened end and set off (6)
I believe the answer is:
tensed
'tightened' is the definition.
(tensing is a kind of tightening)
'end and set off' is the wordplay.
'and' says to put letters next to each other.
'off' is an anagram indicator.
'end'+'set'='endset'
'endset' is an anagram of 'TENSED'.
(Another definition for tensed that I've seen is " under strain".)
I've seen this clue in The Mirror.
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