Tire — part of a Buick? (7)
I believe the answer is:
exhaust
I believe this clue is a double definition.
'tire' is the first definition.
(exhausting is a kind of tiring)
'part of a buick?' is the second definition.
(part of a Buick car)
(Other definitions for exhaust that I've seen before include "Drain completely" , "Waste gas from engine" , "Car's fume pipe" , "Tire out - waste gases from engine" , "lower part of estate?" .)