Tireless debating if ale is drunk (13)
I believe the answer is:
indefatigable
'tireless' is the definition.
(synonyms)
'debating if ale is drunk' is the wordplay.
'is drunk' indicates an anagram.
'debating'+'if'+'ale'='debatingifale'
'debatingifale' is an anagram of 'INDEFATIGABLE'.
(Other definitions for indefatigable that I've seen before include "Unflagging" , "Unremitting" , "Tireless" , "with no end of energy" , "Persistent" .)