Titled lady upset crazy European (4)
I believe the answer is:
dame
'titled lady' is the definition.
(dame is a title given to a woman)
'upset crazy european' is the wordplay.
'upset' shows that the letters should be reversed in order.
'crazy' becomes 'mad' (synonyms).
'european' becomes 'e' (abbreviation e.g. EU).
'mad' in reverse letter order is 'dam'.
'dam'+'e'='DAME'
(Other definitions for dame that I've seen before include "See 21" , "Pantomime character" , "She's played by a man in panto" , "Man's panto role" , "Pantomime role played by a man" .)