To feel unwell upsets Ali (3)
I believe the answer is:
ail
'to feel unwell' is the definition.
(I've seen this in another clue)
'upsets ali' is the wordplay.
'upsets' indicates an anagram.
'ali' anagrammed gives 'AIL'.
(Other definitions for ail that I've seen before include "Afflict -- feel unwell" , "Be unwell, feel poorly" , "Afflict; suffer" , "Trouble, afflict; be sickly" , "Sink" .)