Crossword Genius

To guard against infection I clean out potty (9)

Ross

I believe the answer is:

inoculate

'to guard against infection' is the definition.

'i clean out potty' is the wordplay.
'potty' indicates anagramming the letters.
'clean'+'out'='cleanout'
'cleanout' anagrammed gives 'noculate'.
'i'+'noculate'='INOCULATE'

(Other definitions for inoculate that I've seen before include "Introduce an idea or attitude into the mind of: immunise" , "Give a jab" , "Imbue" , "give someone the needle" , "Immunise, vaccinate" .)

I've seen this clue in The Times.
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