To run when trouble starts is a bad thing (4)
I believe the answer is:
trot
'to run' is the definition.
(trotting is a kind of running)
'trouble starts is a bad thing' is the wordplay.
'starts' suggests taking the first letters.
'is a bad thing' becomes 'rot' (I can't explain this - if you can you should believe this answer much more).
The first letter of 'trouble' is 't'.
't'+'rot'='TROT'
'when' is the link.
Can you help me to learn more?
(Other definitions for trot that I've seen before include "Brisk movement" , "Red" , "Militant socialist (informal)" , "Radical socialist (abbr) - horse gait" , "Move at brisk pace" .)