To use needles confuses most tinkers (4)
I believe the answer is:
knit
'to use needles' is the definition.
(I've seen this before)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for knit that I've seen before include "manufacture clothing?" , "Use needles to make clothes" , "Cause to unite" , "Bind together" , "Join together (with needles)" .)