Topless model filling vacant Penthouse spread (5)
I believe the answer is:
paste
'spread' is the definition.
(synonyms)
'topless model filling vacant penthouse' is the wordplay.
'topless' means to remove the first letter.
'model' becomes 'last' (model used by a shoemaker).
'filling' indicates putting letters inside.
'vacant penthouse' becomes 'pe' (I can't explain this - if you can you should believe this answer much more).
'last' with its initial letter taken away is 'ast'.
'ast' going within 'pe' is 'PASTE'.
(Other definitions for paste that I've seen before include "It may be put on teeth" , "Fake gems; adhesive" , "Adhesive; imitation gem" , "It is used to stick wallpaper" , "Fix with adhesive" .)