Total hassle (4)
I believe the answer is:
pain
'total hassle' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for pain that I've seen before include "Bodily suffering or mental anguish" , "Suffering, ache" , "French bread?" , "Symptom of hurt or disorder" , "Suffering of body or mind" .)