Total runs one piled up including nothing on a big scale (8)
I believe the answer is:
enormous
'on a big scale' is the definition.
(enormous means very big)
'total runs one piled up including nothing' is the wordplay.
'total' becomes 'sum' (synonyms).
'runs' becomes 'r' (cricket abbreviation).
'piled up' shows that the letters should be reversed in order.
'including' is an insertion indicator.
'nothing' becomes 'O' (O resembles 0).
'sum'+'r'+'one'='sumrone'
'sumrone' reversed gives 'enormus'.
'enormus' going around 'o' is 'ENORMOUS'.
(Other definitions for enormous that I've seen before include "Fat" , "Huge, really big" , "Mammoth" , "'Huge, gigantic (8)'" , "Tremendous, gigantic" .)