Towels off most down (6)
I believe the answer is:
lowest
'most down' is the definition.
('low' can be similar in meaning to 'down')
'towels off' is the wordplay.
'off' indicates an anagram.
'towels' with letters rearranged gives 'LOWEST'.
(Other definitions for lowest that I've seen before include "Given maximum reduction" , "Smallest number" , "Nethermost" , "Furthest down" , "(Of number) least" .)