Tragedy of feline pet throttled by alpha male (11)
I believe the answer is:
catastrophe
'tragedy' is the definition.
(synonyms)
'feline pet throttled by alpha male' is the wordplay.
'feline' becomes 'cat' (cat is a kind of feline).
'pet' becomes 'strop' (both can mean a tantrum).
'throttled by' is an insertion indicator (inserted letters get throttled or smothered).
'alpha' becomes 'a' (phonetic alphabet: alpha, bravo, charlie etc.).
'male' becomes 'he' (he refers to a man).
'a'+'he'='ahe'
'strop' going within 'ahe' is 'astrophe'.
'cat'+'astrophe'='CATASTROPHE'
'of' is the link.
(Other definitions for catastrophe that I've seen before include "Event causing great damage" , "disastrous event?" , "Event causing great suffering" , "Denouement" , "Great disaster" .)