Tragic character in place with few inhabitants (6)
I believe the answer is:
hamlet
I believe this clue is a double definition.
'tragic character' is the first definition.
(Shakespeare character)
'place with few inhabitants' is the second definition.
(a hamlet is a small village)
'in' acts as a link.
(Other definitions for hamlet that I've seen before include "Danish king in play" , "Tiny village; Prince of Denmark" , "Shakespeare's tragic Prince of Denmark" , "Thelma (anag) - play" , "Small village for Shakespearian prince" .)