Transplant may give one fresh courage (3,5)
I believe the answer is:
new heart
'transplant' is the definition.
I don't know anything about this answer so I can't tell whether this works.
'give one fresh courage' is the wordplay.
'give' means one lot of letters go next to another.
'one fresh' becomes 'new' (I've seen this before).
'courage' becomes 'heart' (heart is a kind of courage).
'new' next to 'heart' is 'NEW HEART'.
'may' acts as a link.
Can you help me to learn more?
(Another definition for new heart that I've seen is " Fresh enthusiasm (or a transplant?)".)