Trap men - he's mad (6)
I believe the answer is:
enmesh
'trap' is the definition.
(I've seen this in another clue)
'men he's mad' is the wordplay.
'mad' is an anagram indicator.
'men'+'hes'='menhes'
'menhes' anagrammed gives 'ENMESH'.
(Other definitions for enmesh that I've seen before include "Make tangled as if in a net" , "Entangle as in net" , "trap" , "Men she changed to entangle" , "Catch in toils" .)